Tangles, inspired by Sarah Leavitt's memoir "Tangles: A Story about Alzheimer's, My Mother and Me," is a hand-drawn animation that Rogen and his wife Lauren Miller Rogen helped produce. Leavitt, who joined them at Cannes, noted the adaptation took about 10 years. "Every frame has a human touch to it, which is great," Rogen said. The film premiered at Cannes on May 14 and features a voice cast including Julia Louis-Dreyfus, Bryan Cranston, Beanie Feldstein and Sarah Silverman, among others.
Lauren and Seth have long been vocal about Alzheimer's: caring for Lauren's late mother, Adele, who was diagnosed with genetic early-onset Alzheimer's at 55, inspired their documentary Taking Care and their nonprofit Hilarity for Charity, founded in 2012. Leavitt stressed that AI can only regurgitate what it's fed and cannot replicate the lived creative process or the personal history behind Tangles.